FAILURE OF A TYROSINE-CONTAINING MIXTURE TO INFLUENCE THE PRODUCTION. OF EPINEPHRINE IN EXPERIMENTAL ANIMALS

¹ Department of Pharmacology and Therapeutics, Stanford University, School of Medicine, San Francisco, California

The reported anti-allergic and epinephrine-producing effects of a tyrosineniacinamide-pyridoxine mixture (Tyral) were investigated.

Rats fed diets containing 4 per cent of this mixture showed no increase in blood pressure, adrenal weight or epinephrine content of the adrenals after periods of feeding of 3 to 12 weeks.

Guinea pigs fed diets containing 4 per cent of the mixture showed no evidence of protection from mild anaphylactic shock.

The claims made for this mixture as an effective epinephrine precursor and as an anti-allergic agent were not confirmed in experimental animals.