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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 3, 268-273, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF CORTISONE ON THE NUCLEOPROTEINS OF CERTAIN NORMAL AND MALIGNANT MOUSE TISSUES

Allan D. Bass 1 and A. Hope McArdle 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The DNA per average nucleus is reduced in liver tissue from cortisone treated mice, whereas cortisone produced no such change in malignant liver tissue taken from the same animal.

Whereas liver RNA is not altered by cortisone, tumor RNA is reduced.

Large doses of cortisone caused a slight but significant reduction in liver nitrogen but no such change was observed in tumor tissue.

A lack of correlation between RNA and nitrogen content in the tumor tissue after cortisone treatment has been demonstrated.

Submitted on July 2, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.