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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 257-260, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ACETYLCHOLINE AND ESERINE ON SPONTANEOUS MUSCULAR MOVEMENT IN FISH EMBRYOS

Floyd J. Brinley 1

1 University of Toledo, Toledo, Ohio

Experiments on fish embryos, Aequedens partalegrensis and Oryzias latipes demonstrated that:

1. Acetylcholine and eserine have no significant effect on the muscular activity of uninnervated somatic muscles.

2. The action of both drugs on the innervated muscles results in an initial stimulation, followed by tetany and finally a refractory period.

3. The place of action of acetylcholine appears to be on the motor end plate.

4. There seems to be no significant difference between the effect of exogenous acetylcholine and endogenous acetylcholine which is allowed to accumulate by inactivation of the cholinesterase with eserine.

Submitted on July 1, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.