JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Orahovats, P. D.
Right arrow Articles by Lehman, E. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Orahovats, P. D.
Right arrow Articles by Lehman, E. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 246-251, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL STUDIES OF MIXTURES OF NARCOTICS AND N-ALLYLNORMORPHINE

Peter D. Orahovats 1, Charles A. Winter 1, and Edward G. Lehman 1

1 Merck Institute for Therapeutic Research, Rahway, New Jersey

1 . Experiments in animals have shown that administration of a potent analgesic (morphine) and a limited amount of an analgesic antagonist (nalorphine) in a mixture, has the effect of substantially reducing or eliminating the objectionable side reactions of the potent analgesic without significant loss of the analgesic activity.

2. The results presented in this paper indicate that the optimal dose ratios of analgesic/antagonist mixtures are different for the different analgesics used; it appears that a suitable dose ratio of morphine/nalorphine in rats is 32 parts of morphine to 1 part of nalorphine. A suitable dose ratio of 6-methyl-Dgr6-desoxymorphine/nalorphine, on the other hand, appears to be 2 parts of the narcotic to 1 part of the antagonist. In dogs, a suitable dose ratio was found to be 2 parts of morphine to 0.15 parts of nalorphine.

3. The morphine/nalorphine mixtures given intravenously in dogs and cats showed no significant effects on blood pressure and respiration in contrast to the depressant effects of morphine, given alone at the same dose levels.

Submitted on June 30, 1954




This article has been cited by other articles:


Home page
 Arch OphthalmolHome page
J. E. HARRIS
PHARMACOLOGY AND TOXICOLOGY
Arch Ophthalmol, August 1, 1955; 54(2): 262 - 299.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.