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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 202-209, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF EPINEPHRINE ON THE ANAEROBIC OR THE IODOACETATE-TREATED RAT'S DIAPHRAGM

Sydney Ellis 1 and Sibyl B. Beckett 1

1 Department of Pharmacology, Temple University School of Medicine, Philadelphia 40, Pennsylvania

1. At 27°C. under anaerobic conditions the rat's phrenic-diaphragm preparation contracted in response to direct electrical stimulation for many hours. In some preparations contraction of the muscle in response to indirect stimulation through the nerve was not completely suppressed by anaerobic conditions.

2. At 27°C. iodoacetate-poisoning sufficient to prevent anaerobic function of the diaphragm did not interfere with aerobic function. Bloom et al. (1953) have shown that an active non-glycolytic pathway for oxidative metabolism of glucose is not present in the rat diaphragm.

3. Neuromuscular block was produced by IAA-poisoning at 27°C. and neuromuscular transmission was restored by lactate or pyruvate.

4. The positive inotropic effect of epinephrine on the diaphragm was present in the anaerobic or the IAA-poisoned diaphragm. Possible sites of action eliminated by these observations are discussed.

Submitted on June 25, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.