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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 185-190, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ANTAGONISM OF ERGOT ALKALOIDS TOWARDS THE INHIBITORY RESPONSE OF THE ISOLATED RABBIT INTESTINE TO EPINEPHRINE AND NOREPINEPHRINE

E. Rothlin 1, H. Konzett 1, and A. Cerletti 1

1 Pharmacological Laboratory, Sandoz Ltd., Basle, Switzerland

Hexamethonium and atropine in doses sufficient to abolish the effect of nicotine and acetylcholine do not interfere with the antagonism of the ergot alkaloids ergotamine, dihydroergotamine and dihydroergocornine towards the epinephrine- and norepinephrine-induced inhibition of the pendulum movements of the isolated rabbit intestine.

This rules out the possibility of the antagonism of the ergot alkaloids towards this inhibitory effect of epinephrine and norepinephrine being due to any stimulating effect on the intramural ganglia or to a potentiating action on cholinergic responses in the intestine.

The papaverine-induced inhibition of the pendulum movements of the isolated rabbit intestine is not antagonized by these alkaloids in doses sufficient to antagonize the effect of epinephrine and norepinephrine.

The antagonism of the ergot alkaloids to the inhibitory action of epinephrine and norepinephrine on the intestine is therefore specific.

Submitted on June 21, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.