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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 176-184, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE ANTI-HYPERTENSIVE ACTION OF 2,3-DIARYLALKANONITRILES

F. M. Sturtevant 1, F. J. Saunders 1, and W. E. Hambourger 1

1 Division of Biological Research, G. D. Searle & Co., Box 5110, Chicago 80, Ill.

Of a series of diarylalkanes tested for depressor activity on renal and metacorticoid (post-DCA) hypertension in rats, two nitriles were equally active. These were 2,3-bis(p-hydroxyphenyl)valeronitrile and the corresponding propionitrile.

The valeronitrile also displayed estrogenic activity, growth inhibition, and adrenal hypertrophy in rats; large doses induced severe hemorrhagic responses in dogs. At comparable doses of the propionitrile, these effects were minimal or absent.

In general, it was found that relatively few alterations in the molecule were consistent with anti-hypertensive activity.

Submitted on June 19, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.