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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 151-157, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

MODIFICATION OF TRAUMATIC SHOCK BY ADRENERGIC BLOCKING AGENTS

E. Z. Levy 1, W. C. North 1, and J. A. Wells 1

1 Department of Pharmacology, Northwestern University Medical School, Chicago, Illinois

Normal rats survive trauma induced by tumbling and die in the ensuing 24 hours. If pretreated with adrenergic blocking agents such as Dibenzyline, dihydroergotamine, phentolamine, SY-28, piperoxan or tolazoline the mortality from the tumbling procedure is significantly reduced. A significant number of the treated animals do not survive the period of trauma. The number of such animals depends upon the dose of the drug and the severity of the trauma.

If these drugs act by virtue of their adrenergic blocking properties, it may be assumed that sympathetic discharge is a protective mechanism during physical assault but initiates other processes which are ultimately detrimental to survival.

Submitted on June 12, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.