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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 2, 133-137, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EXCRETORY PRODUCTS OF DIGOXIN IN THE RAT

E. E. Shepheard 1, R. H. Thorp 1, and S. E. Wright 1

1 Department of Pharmacology, University of Sydney, Sydney, Australia

The cardio-active urinary excretion products in rat urine after digoxin administration have been studied by paper chromatography and measured quantitatively by the embryonic chick heart method.

Approximately 10 per cent of the dose of digoxin is excreted in the first 24 hours in the form of active metabolites.

A cardio-active metabolite of digoxin which is not digoxigenin but which retains the unsaturated lactone ring has been detected in rat urine.

Submitted on May 11, 1954




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 Arch Intern MedHome page
J. E. DOHERTY, W. H. PERKINS, and G. K. MITCHELL
Tritiated Digoxin Studies in Human Subjects
Arch Intern Med, October 1, 1961; 108(4): 531 - 539.
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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.