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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 1, 73-79, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

CARDIOVASCULAR, EMETIC AND PHARMACODYNAMIC PROPERTIES OF CERTAIN VERATRUM ALKALOIDS

Benedict E. Abreu 1, Alice B. Richards 1, William M. Alexander 1, and Lawrence C. Weaver 1

1 Research Department, Pitman-Moore Company, Division of Allied Laboratories, Indianapolis, Indiana

1. Ranked in the order of their relative hypotensive potency from greatest to least, the preparations investigated may be arranged as follows: protoveratrine A = germitetrine B = Veralba rang protoveratrine B rang Unitensen.

2. No dissociation of hypotensive from emetic activity was observed with protoveratrine A, Veralba or Unitensen.

3. Protoveratrine A reduces arterial pressure in the dog by acting upon receptors whose impulses travel to the vasomotor center via the vagi and the carotid sinus nerves.

Submitted on April 23, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.