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Journal of Pharmacology And Experimental Therapeutics, Vol. 112, Issue 1, 55-63, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

INHIBITORY EFFECTS OF beta-DIETHYLAMINOETHYL DIPHENYLPROPYLACETATE ON A VARIETY OF DRUG METABOLIC PATHWAYS IN VITRO

Jack R. Cooper 1, Julius Axelrod 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland

beta-Diethylaminoethyl diphenylpropylacetate HCl (SKF 525-A) inhibits the enzyme systems in liver slices and homogenates which oxidize the sidechains of pentobarbital, secobarbital, and hexobarbital; dealkylate meperidine, Dibenamine, aminopyrine and its diethyl analogue; deaminate amphetamine; cleave the ether linkage in codeine; and conjugate morphine.

Diphenylpropylacetic acid, a hydrolytic product of SKF 525-A is equally active at a cellular level, though less active in the intact animal.

It is concluded that SKF 525-A inhibits a factor or factors that a diversity of drug enzyme systems possess in common.

Submitted on April 19, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.