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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 4, 483-488, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

TOXICITY IN MICE OF NEW SECONDARY NITROGEN MUSTARDS

Alexander M. Rutenburg 1, Arnold M. Seligman 1, Lester Persky 2, and Orrie M. Friedman 3

1 Yamins Laboratory for Surgical Research, Beth Israel Hospital, and the Department of Surgery, Harvard Medical School, Boston, Mass.
2 Lakeside Hospital, Cleveland, Ohio
3 School of Science, Brandeis University, Waltham, Mass.

A comparison of the toxicity of mice of various secondary nitrogen mustards was made with the toxicity of methyl bis (beta-chloroethyl) amine. These secondary nitrogen mustards were capable of intramolecular cyclization to yield potent tertiary amine mustards. The secondary nitrogen mustards when converted to N-phosphonyl derivatives were much less toxic. Suitable phosphoryl derivatives of the new secondary nitrogen mustards may turn out to be chemotherapeutic agents for tumors with high phosphamidase activity.

Submitted on April 29, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.