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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 4, 469-474, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

$$Word$$ PHARMACOLOGIC ACTIVITY OF THE OPTICAL ISOMERS OF ISOPROPYLARTERENOL (ISUPREL) COMPARED WITH THAT OF THE OPTICALLY INACTIVE ANALOG 1-(3,4-DIHYDROXY PHENYL)-2-ISOPROPYLAMINOETHANE HCl

A. M. Lands 1, F. P. Luduena 1, and B. F. Tullar 1

1 Sterling-Winthrop Research Institute, Rensselaer, New York

Racemic isopropylarterenol has been resolved into optical isomers and these purified until no further change in pharmacologic potency was observed. Results obtained with the purified material have given the following l/d activity ratios: blood pressure of the cat, 600-1600:1; of the dog, 300-600:1; uterus of the cat in situ, 200-800:1; the isolated rat uterus, 800-1600:1. The optically inactive analog, 1-(3,4-dihydroxyphenyl)-2-isopropylaminoethane HCl, is somewhat less active and more toxic than the most highly purified sample of d-isopropylarterenol used in this investigation.

The dextro isomer is approximately half as toxic as the levo isomer.

Submitted on April 23, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.