PHARMACOLOGY OF SIXTY-FOUR CARDIAC GLYCOSIDES AND AGLYCONES

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

Sixty-four digitalis-like glycosides, aglycones, and their derivatives were assayed in etherized cats. In case of inactive compounds they were tested out in another species of animals, the frog, for confirmatory purposes. Certain generalizations as well as exceptions between chemical structure and cardiac activity were pointed out. Tanghinigenin and 5-anhydro-periplogenone definitely had both cardiac and convulsant action. Sample experiments on electrocorticogram, electrocardiogram, the dog's heart lung preparation and the myogram of the frog's ventricle were carried out with a few active substances.