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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 3, 360-364, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF N-ALLYLNORMORPHINE UPON THE ANTIDIURETIC ACTION OF MORPHINE

Charles A. Winter 1, C. Elizabeth Gaffney 1, and Lars Flataker 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

The antidiuretic effect of morphine is effectively blocked by nalorphine. Nalorphine by itself has neither a diuretic nor an antidiuretic action, nor does it antagonize the antidiuretic effect of vasopressin.

The urine of morphinized rats contains an antidiuretic substance which is not morphine, and which is not antagonized by nalorphine. The urine of rats given both morphine and nalorphine does not contain this substance.

The evidence suggests that morphine stimulates the release of antidiuretic hormone from the posterior lobe of the pituitary, and that nalorphine blocks this action of morphine. The site of action is considered to be the hypothalamus.

Submitted on March 25, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.