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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 3, 285-292, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE DIURETIC ACTIVITY OF ISOCYTOSINES

C. G. Van Arman 1

1 Division of Biological Research, G. D. Searle and Co., Chicago 80, Illinois

A series of 34 isocytosine compounds has been investigated for diuretic properties. Some conclusions on the relation of structure to activity are presented. SC-3858 is orally active in the rat at 5 mgm./kgm. and is approximately 360 times as potent as urea. It is only weakly active in the dog by the oral route. The effect on renal hemodynamics, if any, is a slight rise in filtration rate and renal blood flow. The mode of action seems to resemble that of xanthines.

Submitted on March 1, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.