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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 2, 176-181, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

ASCORBIC ACID IN AROMATIC HYDROXYLATION. III. EFFECT OF ASCORBIC ACID ON HYDROXYLATION OF ACETANILIDE, ANILINE AND ANTIPYRINE IN VIVO

Julius Axelrod 1, Sidney Udenfriend 1, and Bernard B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare, Bethesda 14, Maryland

The rate of hydroxylation of acetanilide, aniline and antipyrine is markedly reduced in guinea pigs depleted of ascorbic acid. On repletion of the animals with ascorbic acid the rate of hydroxylation is restored to normal.

The possible role of ascorbic acid in the hydroxylation of drugs of aromatic character is discussed.

Submitted on February 11, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.