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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 2, 161-168, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF PENTOBARBITAL ON THE INOTROPIC RESPONSES OF THE ISOLATED FROG HEART TO EPINEPHRINE AND ACETYLCHOLINE

Walter W. Baker 1

1 Department of Pharmacology, Jefferson Medical College, Philadelphia 7, Pennsylvania

1. The inotropic effects of epinephrine and acetylcholine were studied independently of their chronotropic actions in the isolated frog heart. These agents when present together appeared to act independently on the amplitude, but only the net effect was observed.

2. The ratio of epinephrine to acetylcholine in the perfusion medium governed the amplitude of contraction. The balanced response for a given ratio was readily upset by some drugs.

3. The depressant effects of pentobarbital and acetylcholine were additive, but only the acetylcholine depression was blocked by atropine.

4. The inotropic response to epinephrine was blocked by pentobarbital. Both drugs were mutually antagonistic throughout a range of concentrations.

5. Prior perfusion with pentobarbital upset the epinephrine-acetylcholine balance.

6. Hexethal and phenobarbital acted similarly to pentobarbital, but quantitatively their effectiveness was related to their relative depressant action on the frog heart. Some drugs, however, depressed the heart without antagonizing epinephrine.

Submitted on February 8, 1954






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.