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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 2, 152-160, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE PHARMACOLOGY OF N-ALLYLNORMORPHINE

Charles A. Winter 1, Peter D. Orahovats 1, Lars Flataker 1, Edward G. Lehman 1, and Jane T. Lehman 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

N-allylnormorphine (nalorphine) possesses no more than slight analgesic effect as measured by reaction to thermal stimuli in animals.

Nalorphine is an effective antagonist against a wide variety of potent analgesics related pharmacologically to morphine, whether related chemically or not. It antagonizes many times its molecular equivalent of narcotics.

The antagonism is exhibited against a wide spectrum of biological effects of analgesic drugs. Nalorphine probably competes with these drugs at the sites of action.

Nalorphine exhibits very weak antispasmodic activity.

Submitted on February 2, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.