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Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 2, 131-141, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF beta-DIETHYLAMINOETHYLDIPHENYLPROPYL-ACETATE HYDROCHLORIDE (SKF NO. 525-A) ON HEXOBARBITAL

Leonard Cook 1, John J. Toner 1, and Edwin J. Fellows 1

1 Research and Development Division, Smith, Kline and French Laboratories, Philadelphia, Pennsylvania

SKF No. 525-A markedly prolonged the hypnotic action of hexobarbital in mice and rats without significantly altering the toxicity of the hypnotic agent. The duration of hexobarbital action was increased over 37 times in rats by SKF No. 525-A treatment. This agent has equal activity orally or intraperitoneally, the oral route being least toxic. It is active almost immediately after administration and its duration of action is approximately fifteen hours. The degree of hexobarbital prolongation increases progressively with the dose of SKF No. 525-A. This compound prolongs hexobarbital hypnosis to achieve a duration of sleeping time which is impossible to attain with any dose of hexobarbital alone.

Submitted on January 9, 1954




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.