JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holland, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holland, W. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 111, Issue 1, 1-8, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ANESTHETIC AGENTS ON THE LOSS OF POTASSIUM FROM ISOLATED GUINEA PIG AURICLES

William C. Holland 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Concentrations of magnesium chloride, pentobarbital, chloretone, procaine and cocaine causing 50-80 per cent reduction in the amplitude of auricular contractions decrease the rate of K loss from these preparations.

The decrease in K ion permeability produced by the agents can be partially or completely prevented by addition of relatively small quantities of acetylcholine (10-5 M) and ATP (5 x 10-6 M) to the suspending medium.

It is postulated that the release and subsequent combination of acetylcholine with the receptor protein-cholinesterase is the process that normally accelerates ion movement across the myocardial membrane. The anesthetic agents could effectively diminish transfer of K across the cell membrane by interfering with normal functioning of the K ion accelerating mechanism either directly or indirectly.

Submitted on November 16, 1953




This article has been cited by other articles:


Home page
 Arch SurgHome page
T. M. Kamiyama, W. R. Webb, and R. R. Ecker
Preservation of the Anoxic Heart With a Metabolic Inhibitor and Hypothermia
Arch Surg, May 1, 1970; 100(5): 596 - 599.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.