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Correction for Maxwell et al., J Pharmacol Exp Ther 109 (3) 274-283.
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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 4, 470-470, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF EPINEPHRINE AND TYPHOID VACCINE ON SEGMENTAL VASCULAR RESISTANCES IN THE HUMAN KIDNEY

Morton H. Maxwell 1, Domingo M. Gomez 1, Alfred P. Fishman 1, and Homer W. Smith 1

1 Department of Physiology, New York University College of Medicine, New York 16, N. Y.

The following summary was omitted in the article by Maxwell et al.: This Journal, 109: 274, 1953.

The present study is a re-examination of the renal vasomotor changes associated with epinephrine ischemia and typhoid vaccine hyperemia in man, utilizing the premises and methods of Gomez for evaluation of renal resistances. This method of analysis has previously demonstrated that filtration equilibrium is not reached in the glomerulus, and that calculations of renal resistances based on the premise are invalid. The present results indicate that all segments of the renal vasculature participate in vasomotor changes but that in both epinephrine ischemia and typhoid vaccine hyperemia, the most significant changes in resistance occur in the afferent arteriolar and venular segments of the kidney. The Richards and Plant paradox, i.e. simultaneous increased vascular resistance and increased volume of the animal kidney perfused with epinephrine, appears by this type of analysis to be due not to increased efferent arteriolar resistance but to an increase in intravenal vascular volume caused by increased renal venular resistance.






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.