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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 4, 451-457, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE PHYSIOLOGIC DISPOSITION OF PHENYLINDANEDIONE IN MAN

Arthur R. Schulert 1 and Murray Weiner 1

1 Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital, Welfare Island, New York 17, New York

1. A method is described for the estimation of phenylindanedione in plasma and urine.

2. Phenylindanedione is rapidly and essentially completely absorbed from the gastrointestinal tract.

3. Metabolic transformation in man is more rapid than that of Dicumarol and slower than that of Tromexan.

4. Duration of prothrombin response bears the same relationship to duration of drug level as has previously been noted with the coumarins.

5. Individual differences in rate of biotransformation and prothrombin response are similar to the differences previously noted with Dicumarol and Tromexan.

Submitted on December 22, 1953




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.