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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 4, 392-397, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

EXCRETION OF SUCCINYLDICHOLINE IN URINE OF CAT AND MOUSE

Stata Norton 1 and E. J. de Beer 1

1 Wellcome Research Laboratories, Tuckahoe 7, New York

1. The contracture of frog rectus abdominis preparation produced by succinyldicholine was used as a basis for estimation of succinyldicholine in urine.

2. Mice and cats were found to excrete measurable amounts of succinyldicholine in the urine within one-half hour after administration.

3. Most animals excreted from 5 to 15 per cent of the dose administered. The remaining succinyldicholine is presumably destroyed in the body.

Submitted on November 11, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.