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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 352-360, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE EFFECTS OF EPINEPHRINE AND LEVARTERENOL IN THE INTACT ANESTHETIZED DOG

Raymond P. Ahlquist 1, James P. Taylor 1, Clarence W. Rawson Jr. 1, and Virginia L. Sydow 1

1 Department of Pharmacology, Medical College of Georgia, Augusta, Georgia

The comparative effects of equimolar doses of levarterenol (l-norepinephrine) and epinephrine have been determined in anesthetized dogs.

Levarterenol was found to be significantly more effective than epinephrine as a pressor agent and in producing vagal bradycardia.

Epinephrine was found to be significantly more effective in producing splenic contraction, intestinal relaxation, and vasoconstriction in the renal and femoral vascular beds.

Submitted on November 19, 1953




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.