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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 334-338, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF HEART RATE UPON THE LETHAL DOSE OF VERATRIDINE IN THE HEART-LUNG PREPARATION OF THE DOG

Joseph M. Benforado 1 and Peter N. Witt 1

1 Department of Pharmacology, Harvard Medical School, Boston 15, Massachusetts

In thirteen heart-lung preparations of the dog the lethal dose of veratridine, calculated as the infused amount of drug per gram of heart, was determined. The drug was infused at a constant rate of 10 microgm. per minute, and the heart rates were varied by means of an electric stimulator. A significant dependency of lethal dose on average heart rate was found. A possible mechanism for this dependency is suggested.

Submitted on November 7, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.