JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 309-314, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

RENAL TUBULAR SECRETION OF TETRAETHYLAMMOXIUM IN THE DOG AND THE CHICKEN

Barbara R. Rennick 1, Dorothy M. Calhoon 1, Hector Gandia 1, and Gordon K. Moe 1

1 Department of Physiology, State University of New York, Upstate Medical Center, Syracuse 10, New York

1. At low plasma concentrations, TEA clearance in dogs is about 3 times greater than creatinine clearance.

2. A Tm is reached at 3-5 microgm. per ml. of TEA in the plasma and the maximum secretory capacity is from 1-1.4 mgm. per mm. per m2.

3. TEA is rapidly secreted by the chicken kidney.

Submitted on November 2, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.