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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 304-308, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE EVALUATION OF SOME N-SUBSTITUTED ARTERENOL DERIVATIVES AS BRONCHODILATORS

R. A. Seibert 1 and Carroll A. Handley 1

1 Department of Pharmacology, Baylor University College of Medicine, Houston, Texas

A modified method has been developed to determine the relative activity of compounds as bronchodilators in the anesthetized dog. The method utilizes an infant respirator (Iron Lung) to maintain a constant respiratory pressure in curarized dogs.

By slow infusion of the curare-like drug, voluntary respiration can be abolished without producing bronchoconstriction or a lowering of the blood pressure.

A series of compounds has been tested, all of which are N-substituted arterenol derivatives. The most active compound JB-245 (N-2-(1-(4-methoxyphenyl)-propyl)arterenol) has approximately the same activity as Isuprel as a bronchodilator.

Submitted on November 2, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.