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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 300-303, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

CORONARY DILATOR ACTION. III. EFFECT OF SEVERAL ANTIHISTAMINE COMPOUNDS ON CORONARY BLOOD FLOW IN THE INTACT DOG

Martin M. Winbury 1

1 Division of Biological Research, G. D. Searle & Co., P. O. Box 5110, Chicago 80, Illinois

The coronary dilator action of six antihistamine compounds was studied quantitatively in the intact dog. All of the compounds appeared to have some activity and are in the following descending order of potency: RP-3015, Phenergan, Diphenhydramine, Diparcol, Neoantergan, Pyribenzamine. There appeared to be no direct relationship between coronary dilator activity and antihistamine activity. The coronary dilatation following intracoronary injection occurred without any consistent change in blood pressure, heart rate, stroke volume, cardiac output, total peripheral resistance, or cardiac work. Coronary resistance was always reduced. RP-3015 was found to be effective after intravenous injection.

Submitted on October 24, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.