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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 3, 293-299, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE EFFECT OF HYDROCHOLERETIC AGENTS ON HEPATIC EXCRETORY MECHANISMS

D. L. Cook 1, Coleta A. Lawler 1, and D. M. Green 2

1 Division of Biological Research, G. D. Searle & Co., Chicago 80, Ill.
2 University of Southern California School of Medicine, Los Angeles, California

Studies were made of the effects of two hydrocholeretic agents, dehydrocholic acid and beta-(2,4-dimethoxy-5-cyclohexylbenzoyl) propionic acid (SC-2644), on the rate of biliary excretion and the biliary clearance of a variety of substances, both endogenous and exogenous. Mongrel dogs with acute biliary fistulas were used. Constant infusion techniques were employed to develop equilibrium conditions between plasma and bile before any measurements were made.

The excretory rates and clearances of water, sodium, potassium, chloride and creatinine (substances considered to be primarily filtered) were significantly increased by the two drugs; the clearances of BSP, PAH and penicillin (secreted substances) were not significantly increased.

These results are interpreted as indicating that the primary mechanism involved in hydrocholeresis is an increase in a filtration process.

Submitted on October 19, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.