POTENTIATION OF DRUG-PRODUCED EJACULATION BY -DIETHYLAMINOETHYLDIPHENYLPROPYLACETATE (SKF No. 525A)

¹ Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

1. -Diethylaminoethyldiphenylpropylacetate greatly enhanced not only the hypnotic but also the ejaculatory effectiveness of Pernoston-yohimbine combinations in the albino mouse.

2. Both with and without the enhancer, the hypnotic effect of the combination, measured as "sleep duration", increased with increasing Pernoston doses combined with a constant yohimbine dose. It also increased with increasing yohimbine doses and constant Pernoston dose, which reveals that yohimbine also potentiates this Pernoston effect.

3. The ejaculatory effect, measured by the incidence of ejaculating individuals, also depended on the Pernoston dose. However, both with and without the enhancer, the transition from practically no response to response in almost all individuals of the population occurred in the presence of a constant "optimal" yohimbine dose in a narrow range of Pernoston dosage, within which the hypnotic effect passed a certain "threshold ejaculatory value."

4. When the "optimal" Pernoston dose was combined with increasing yohimbine doses, the incidence of ejaculating animals increased only gradually, parts of the population responding to markedly less than the optimal yohimbine dose.

5. From the relations between the doses of the three drugs and the two effects studied, an interpretation is derived both of the mechanisms by which Pernoston and yohimbine cooperate in the coalitive ejaculatory effect and of the mechanism by which the enhancer drug influences the combined effect.