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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 2, 241-243, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF THE LIVER IN THE DEMETHYLATION OF N-METHYL DERIVATIVES OF HYDANTOIN AND OF 2,4-OXAZOLIDINEDIONE

Thomas C. Butler 1 and William J. Waddell 1

1 Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Partial hepatectomy in the rat results in a large decrease in the rate of demethylation of l-Mesantoin and of trimethadione.

It is concluded that the liver is the principal, if not the only, site of the demethylation of these drugs.

The suggestion is made that the liver is probably the principal site of demethylation not only of N-methyl derivatives of barbituric acid, hydantoin, and 2,4-oxazolidinedione but also of analogous compounds of other chemical types.

Submitted on October 5, 1953






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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.