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-DIMETHYLAMINOPROPYL)-2-CHLOROPHENOTHIAZINE (CHLORPROMAZINE) IN DOG AND CAT
1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City
Chlorpromazine, 10-(
-dimethylaminopropyl)-2-chlorophenothiazine hydro-chloride, a non-antihistaminic congener of Phenergan, was tested for its efficacy against apomorphine-induced emesis in 6 standardized dogs; the drug was also tested against morphine, ergot (Hydergine), intravenous and oral copper sulfate, lanatoside-C and veratrum (Veriloid). In cats, Chlorpromazine was examined for its ability to prevent vomiting caused by apomorphine, lanatoside-C, veratrum, nitrogen mustard, pilocarpine and intravenous copper sulfate.
In dogs, Chlorpromazine is markedly effective in antagonizing apomorphine-induced emesis, whereas Phenergan showed no protective effect. Chlorpromazine also protects against vomiting evoked by morphine and ergot, but it is ineffective against intravenous copper sulfate, lanatoside-C, veratrum and oral copper sulfate. The pattern of anti-emetic action of Chlorpromazine in dogs suggests that the mechanism of its action is a selective depression of the medullary emetic chemoreceptor trigger zone.
In cats, Chlorpromazine did not prevent vomiting induced by apomorphine, lanatoside-C and intravenous copper sulfate. Attention is called to the anatomic and pharmacologic differences in the emetic chemoreceptor trigger zone of cats and dogs.
The possible relation between the clinical anti-emetic usefulness of Chlorpromazine and its efficacy in laboratory animals is briefly discussed.
Submitted on August 17, 1953
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