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Journal of Pharmacology And Experimental Therapeutics, Vol. 110, Issue 1, 76-85, 1954
Copyright © 1954 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF DRUGS AND METABOLIC ALTERATIONS ON BRAIN STEM AROUSAL MECHANISM

A. Arduini 1 and M. G. Arduini 1

1 Department of Anatomy, School of Medicine, University of California at Los Angeles and Veterans Administration Hospital, Long Beach, California

Recent study has revealed a subcortical arousal mechanism in the reticular formation of the brain stem whose ascending influence upon the cortex is responsible for EEG and behavioral wakefulness.

Activity evoked in this subcortical mechanism by afferent stimulation shows a markedly greater susceptibility to alteration by drugs and metabolic changes than does concomitant discharge conducted to sensory areas of the cortex in direct afferent paths.

It is proposed that while depressant and excitant drugs act upon all complexly organized portions of the central nervous system, their influence upon the subcortical arousal mechanism may account in considerable measure for their generalized effects.

Submitted on August 13, 1953




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Copyright © 1954 by the American Society for Pharmacology and Experimental Therapeutics.