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Journal of Pharmacology And Experimental Therapeutics, Vol. 11, Issue 2, 133-145, 1918
Copyright © 1918 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS ON THE ACTION OF TARTRATES, CITRATES AND OXALATES A STUDY IN TOLERANCE, CUMULATION AND THE EFFECT OF DIET

WILLIAM SALANT 1 and A. M. SWANSON 1

1 From the Pharmacological Laboratory, Bureau of Chemistry, United States Department of Agriculture, Washington, D. C.

1. Tolerance to tartrate may be acquired by rabbits on different diets, the doses survived being about two to three times the surely fatal dose. No increased resistance to tartrate was observed in cats that received gradually increasing doses.

2. Cumulation was observed in experiments with citrate and oxalate.

3. The resistance to oxalate and citrate in rabbits may be slightly increased by diet.

4. The different behavior of tartrate, citrate, and oxalate as regards tolerance and cumulation is held to be unfavorable to the theory which assumes that the physiological effects of their acids, and soluble salts are due to calcium precipitation or to the transformation of ionic calcium into nonionized calcium in the cell.






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Copyright © 1918 by the American Society for Pharmacology and Experimental Therapeutics.