JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hardman, H. F.
Right arrow Articles by Chenoweth, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hardman, H. F.
Right arrow Articles by Chenoweth, M. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 4, 461-466, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF THE ETHYLENEDIAMINE COMPONENT OF AMINOPHYLLINE ON THE DURATION OF REVERSAL OF CARDIAC FAILURE

Harold F. Hardman 1, Albert C. Yard 1, and Maynard B. Chenoweth 2

1 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan
2 The Dow Chemical Company, Midland, Michigan

1. The ethylenediamine content of Aminophylline contributes significantly to the duration of action of this drug as tested in the failed dog heart-lung preparation.

2. Ethylenediamine exerts a marked positive inotropic action and differs from theophylline in lacking a corresponding positive chronotropic action as tested in the failed dog heart-lung preparation.

Submitted on August 14, 1953






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.