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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 4, 431-443, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF ETHYL ALCOHOL

E. K. Marshall Jr. 1 and William F. Fritz 2

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore, Md.
2 Clinic of General Medicine and Experimental Therapeutics of The National Heart Institute, National Institutes of Health, Bethesda, Maryland

1. The independence of the rate of oxidation of alcohol on the amount present in the organism is only apparently true for relatively high concentrations in plasma. At very low concentrations, in accordance with data obtained on other drugs, the rate of disappearance of alcohol from the plasma (oxidation) is proportional to the amount present.

2. At the usual dosages the rate of oxidation of alcohol is not constant but varies from hour to hour in the same dog.

3. The average rate of oxidation in the same dog varies from day to day.

4. The data available at present are not adequate to determine if the rate of oxidation of alcohol is higher at very high doses than at lower ones.

Submitted on July 27, 1953




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I. R. McManus, A. O. Contag, and R. E. Olson
Characterization of Endogenous Ethanol in the Mammal
Science, January 8, 1960; 131(3393): 102 - 103.
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G. H. NELSON
Ethanol Protection against the Catalase-Depressing Effect of 3-Amino-1,2,4-Triazole
Science, March 7, 1958; 127(3297): 520 - 521.
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