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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 4, 417-421, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

ACTIONS AND ADDICTION LIABILITY OF THE DITHIENYLBUTENYLAMINES IN MAN

Harris Isbell 1 and H. F. Fraser 1

1 National Institute of Mental Health, Addiction Research Center, USPHS Hospital, Lexington, Kentucky

1. Diethylamino- (No. 4185) and ethylmethylamino-1,1-(2'-thienyl)-but-1-ene (No. 5145) induce behavior resembling that seen after administration of morphine in former morphine addicts.

2. No. 5145 relieved and suppressed abstinence from morphine. No. 4185 effectively suppressed abstinence from morphine.

3. On withdrawal of the No. 5145 compound after substitution for morphine, a definite morphine-like abstinence syndrome was observed.

4. On withdrawal of No. 5145, after 30 days experimental direct addiction in three patients, a definite abstinence syndrome was observed.

5. N-Allylnormorphine precipitated abstinence in patients in whom No. 5145 had been substituted for morphine, as well as in the patients who were directly addicted.

6. The dithienylbutenylamines possess addiction liability similar to that of morphine.

Submitted on July 15, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.