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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 4, 413-416, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF N-ALLYLNORMORPHINE UPON THE DEVELOPMENT OF TOLERANCE TO MORPHINE IN THE ALBINO RAT

Peter D. Orahovats 1, Charles A. Winter 1, and Edward G. Lehman 1

1 Merck Institute for Therapeutic Research, Rahway, N. J.

1. In rats injected repeatedly with a mixture of morphine and N-allylnormorphine in which the dose of the latter is too small to inhibit the analgesic effect of the morphine completely, the analgesic effect of the mixture declines more rapidly than it does to morphine alone.

2. It is demonstrated that this result is not due to tolerance to morphine, but to the greater inhibiting effect of N-allylnormorphine on morphine in partially tolerant than in non-tolerant rats.

3. Rats injected chronically with a morphine N-allylnormorphine mixture are less tolerant to morphine than are those injected for an equal length of time with morphine alone.

4. Rats injected chronically with N-allylnormorphine alone are more responsive to morphine than are normal animals.

Submitted on July 13, 1953




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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.