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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 3, 372-376, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

GANGLIONIC BLOCKING ACTION OF ATROPINE AND METHYLATROPINE

Lewis D. Fink 1 and Peter Cervoni 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle 5

The ganglionic blocking action of methylatropine, atropine and TEA was evaluated in cats on the basis of the doses of each drug required to block transmission through the superior cervical ganglion, the carotid sinus vasopressor reflex and the ganglionic stimulating action of DMPP. The results with these three tests show methylatropine to be the most potent and atropine the least potent ganglionic blocking agent.

Submitted on June 20, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.