THE EFFECT OF SODIUM DEHYDROCHOLATE UPON THE OXYGEN UPTAKE OF LIVER AND CEREBRAL CORTEX SLICES OF FED AND STARVED RATS

¹ Department of Pharmacology, School of Pharmacy, The University of Kansas City, Kansas City, Missouri

The effects of 0.00047 M (0.4 mgm.) sodium dehydrocholate and brief starvation upon the oxygen uptake of slices of rat liver and cerebral cortex were studied in vitro using conventional manometric methods. The tissues were maintained in a medium either with or without glucose.

Sodium dehydrocholate in a glucose suspending medium significantly depressed the oxygen uptake of cerebral cortex slices of fed and starved rats. This depression did not occur when the cerebral cortex slices were maintained in the glucose-free medium. Starvation had no effect upon the oxygen uptake of cerebral cortex slices.

Sodium dehydrocholate in a glucose-free medium significantly depressed the oxygen uptake of liver slices of fed rats, but did not depress liver slices from starved rats. When in the glucose containing medium, liver slices from both fed and starved rats were not significantly depressed by 0.00047 M sodium dehydrocholate.