JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koskowski, W.
Right arrow Articles by Mahfouz, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koskowski, W.
Right arrow Articles by Mahfouz, M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 3, 361-365, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE INHIBITORY EFFECTS OF COLCHICINE ON THE GASTRIC SECRETION PRODUCED BY HISTAMINE AND OTHER SECRETAGOGUES

W. Koskowski 1 and M. Mahfouz 1

1 Department of Pharmacology, Faculty of Medicine, School of Pharmacy, Alexandria University

The gastric secretion produced by histamine in pigeons with gastric fistulas could be greatly inhibited by the repeated administration of colchicine. The onset of secretion was delayed, the amount of juice reduced or completely arrested and its acidity greatly lowered. This inhibition was reversible and could be largely prevented by the previous administration of yeast. The degree of this inhibition was greater than that produced by the specific antihistaminic drug, Anthisan.

Colchicine also produced powerful inhibitory effects on the gastric secretion produced by alcohol, whether administered intravenously or intraduodenally, and by histidine-ascorbic acid combination.

At present no satisfactory explanation of the inhibitory effects of colchicine on the gastric secretion and on the hydrochloric acid formation in the oxyntic cells of the gastric mucosa can be given.

Submitted on July 7, 1953






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.