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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 3, 268-273, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HALOGENATION ON THE HYPNOTIC AND ANTICONVULSANT ACTIVITIES OF ACETYLENIC CARBINOLS

S. Y. P'An 1, L. Markarian 1, W. M. McLamore 1, and A. Bavley 1

1 The Research Laboratories, Chas. Pfizer & Co., Inc., Brooklyn, New York

A comparison of the hypnotic and anti-pentylenetetrazole activities of a number of acetylenic carbinols and their halogenated derivatives shows that all compounds in this series possess both types of activity in mice. However, the introduction of halogen into these compounds has a variable effect on central nervous system depression and toxicity. With a few exceptions, these variations in activity or toxicity after halogenation were found to be only of moderate scale.

Submitted on June 17, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.