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1 Laboratory of Chemical Pharmacology and the Laboratory of Kidney and Electrolyte Metabolism of the National Heart Institute, National Institutes of Health, Bethesda, Maryland
Priscoline is secreted by the kidney at a rate limited by the maximal secretory capacity of the tubule cells. The absence of mutual interference between the transport of PAH and Priscoline indicates that the mechanisms for the secretion of these substances are unrelated. Although Priscoline appears not to share in the renal secretory mechanism for N-methylnicotinamide, it has not been possible to establish this with certainty.
Submitted on June 1, 1953