URINARY EXCRETION OF VIOFORM AND DIODOQUIN IN RABBITS

¹ Dept. of Health Education and Welfare, Public Health Service, National Institutes of Health, Laboratory of Tropical Diseases, National Microbiological Institute, Bethesda, Md.

Rabbits were given Vioform or Diodoquin orally once daily for 5 days and the urine collected for 7 days. The daily dosage for Vioform was 20 and 200 to 268 mgm./kgm. and for Diodoquin 20 and 100 to 139 mgm./kgm. The urine samples were analyzed for the free and conjugated drugs and for the free and conjugated metabolic products in which the 8-quinolinol nucleus was intact. The results showed that only the conjugated, unmodified drugs were present in the urine. In the case of Vioform 12 to 15 per cent of the drug was recovered from the urine at the 200 mgm./kgm. dose and 38 to 50 per cent at the 20 mgm./kgm. dose. For Diodoquin, 11 to 16 per cent of the drug was recovered in both the 20 and 100 to 139 mgm./kgm. dosages. The conjugates were shown to be mixtures of the sulfuric and glucuronic acid esters of the respective drugs.