JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guruswami, M. N.
Right arrow Articles by Chenoweth, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guruswami, M. N.
Right arrow Articles by Chenoweth, M. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 2, 136-138, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

REVERSAL OF THE PRESSOR RESPONSE TO CAROTID CLAMPING BY FLUOROACETATE-FLUORIDE MIXTURES

M. N. Guruswami 1 and Maynard B. Chenoweth 1

1 Department of Pharmacology, University of Michigan, Ann Arbor, Michigan

1. A mixture of equal parts of sodium fluoroacetate, 10 per cent, and sodium fluoride, 5 per cent, applied to the carotid sinuses of the dog converts the pressor response to carotid clamping to a depressor response.

2. The effect was not produced by either drug alone, by local anesthesia, or by any other drug or combinations of drugs tried. It is prevented or reversed by glycerol monoacetate.

Submitted on May 6, 1953






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.