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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 1, 26-34, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF PENTOBARBITAL IN MAN AND DOG AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL

Bernard B. Brodie 1, J. J. Burns 1, Lester C. Mark 1, Philip A. Lief 1, Eleonore Bernstein 1, and E. M. Papper 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda, Maryland and the Research Service, Third New York University Medical Division, Goldwater Memorial Hospital, New York, New York and the Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York

A method is described for the estimation of pentobarbital and other oxy-barbiturates in biological fluids and tissues.

Pentobarbital is almost entirely metabolized in man. A major metabolic product is d-5-ethyl-5-(3-hydroxy-1-methylbutyl) barbituric acid.

Unlike thiopental, pentobarbital is not extensively localized in body fat. This explains, in large part, why pentobarbital is not as short acting an anesthetic as thiopental.

In man pentobarbital is metabolized more slowly than thiopental, whereas in the dog the reverse is true. This suggests that the two compounds are metabolized by different biochemical mechanisms.

Submitted on March 14, 1953




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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.