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Journal of Pharmacology And Experimental Therapeutics, Vol. 109, Issue 1, 102-105, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

THE APPEARANCE OF PROCAINE IN THE SPINAL FLUID DURING PERIDURAL BLOCK IN MAN

M. Jack Frumin 1, Herman Schwartz 1, J. J. Burns 1, Bernard B. Brodie 1, and E. M. Papper 2

1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, and the Anesthesia Service, The Presbyterian Hospital, and Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital, New York, N. Y.
2 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Md.

Segmental peridural anesthesia was produced in man by depositing 20 ml. of 2 per cent procaine at approximately the twelfth thoracic vertebral level. The concentration of procaine in the spinal fluid during the anesthesia was about 0.2 mgm. per ml., which is the threshold concentration for spinal block. At least part of the anesthesia during the peridural technique in man is the result of dural penetration of procaine and the subsequent production of spinal anesthesia.

Submitted on April 27, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.