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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 3, 362-363, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics


BLOCKING BY BENODAINE OF THE POTASSIUM EFFECT OF THE RETURN TO SLEEP ON AWAKENING FROM BARBITURATE ANESTHESIA

Paul D. Lamson 1 and Margaret E. Greig 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The return to sleep following the administration of potassium chloride to guinea pigs on awakening from hexobarbital anesthesia was blocked by the adrenergic blocking agent, Benodaine. This would indicate that the potassium effect is mediated by epinephrine.

Submitted on February 5, 1953







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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.