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Journal of Pharmacology And Experimental Therapeutics, Vol. 108, Issue 3, 349-353, 1953
Copyright © 1953 by American Society for Pharmacology and Experimental Therapeutics

CYTOCHROME ENZYMES IN THE BRAIN AND LIVER OF THE CHRONICALLY MORPHINIZED RAT

R. I. H. Wang 1 and J. A. Bain 2

1 Department of Pharmacology, Northwestern Medical School. Chicago. Illinois
2 Departments of Pharmacology and Psychiatry, College of Medicine, University of Illinois, Chicago 12, Illinois

Manometric assay of enzyme levels in the brains and livers from chronically morphinized rats showed that there was a decrease in liver DPN-cytochrome c reductase during morphinization and withdrawal, a slight increase of brain and liver cytochrome c oxidase levels during morphinization followed by a marked depression of this enzyme in both tissues during withdrawal. No changes were observed in the malic dehydrogenase levels of either tissue, nor was brain DPN-cytochrome c reductase activity affected by the morphinization procedures.

Submitted on February 5, 1953






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Copyright © 1953 by the American Society for Pharmacology and Experimental Therapeutics.